Inflammation is generally beneficial and has evolved to promote survival but can also be maladaptive when chronically activated and sustained, leading to progressive tissue injury and reduced survival, as seen in rheumatologic disease and atherosclerosis. Chronic inflammation is not a specific disease but a mechanistic process. The hallmarks of chronic inflammation are the infiltration of primary inflammatory cells such as macrophages, lymphocytes, and plasma cells in the tissue site, producing inflammatory cytokines, proteins, and growth factors that lead to the progression of tissue damage and scar tissue formation. Chronic inflammation can have deleterious effects on the body and often progresses silently, presenting a major threat to the health and longevity. Untreated chronic inflammation generally carries a poor prognosis. Disease-specific morbidity and mortality are dependent on the causative mechanistic process leading to chronic infection. The World Health Organization (WHO) ranks chronic inflammatory disease as the greatest threat to human health. Worldwide 3 of 5 people die due to chronic inflammatory diseases such as stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes. It is critical for clinical researchers to identify the risk factors involved in chronic inflammation and for physicians treating different conditions including autoinflammatory diseases to recognize the insidious effects of long-term chronic inflammation, both learning from other experiences and specialties so that management of this disease can be improved and patients are approached in an holistic way.

During this webinar, the speakers will:

• Describe the molecular mechanisms of, and the current knowledge gaps in, chronic inflammation mostly in autoinflammatory diseases and what can be shared from other rheumatic diseases (lupus, rheumatoid arthritis) and specialties (cardiology, oncology)
• Discuss the impact of chronic inflammation in rheumatic diseases on various organ systems (cardiovascular, musculoskeletal, kidney, and reproductive) and why this is relevant for the subgroup of autoinflammatory diseases
• Provide information to help physicians better survey and follow patients in order to improve long-term outcomes.
  

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