Spatial biology is an emerging field that seeks to understand the spatial organization of cells and how it affects their function. In the context of immuno-oncology, spatial biology has proven to be a critical tool for understanding the interactions between cellular and non-cellular components—cancer cells, immune system, and stroma—within the tumor microenvironment.

Recent advances in imaging technologies, such as multiplex immunofluorescence, have enabled researchers to map the distribution of different cell types within tumors and characterize their functional states. This has led to new insights into the mechanisms of immune evasion by cancer cells and the potential for spatially targeted immunotherapies.

In this webinar, Brian Piening, Cancer Immuno-Genomics Laboratory technical director at Earle A. Chiles Research Institute, Providence, Oregon, and Lubka Roumenina, senior scientist at Centre de Recherche des Cordeliers, Paris, France, will explore the latest developments in spatial biology for immuno-oncology. They will discuss the technologies and methodologies used to study the tumor microenvironment at high resolution, as well as the key biological insights gained from these studies. Additionally, they will examine the potential of identifying spatially relevant biomarkers in new and more effective immunotherapies.

During this webinar, the speakers will:

• Provide an overview of spatial biology and how it compares to traditional immunohistochemistry
• Discuss applications of spatial biology, such as tumor mutational burden and other defined biomarkers, to advance the field of precision immuno-oncology
• Highlight the challenges (e.g., bioinformatics, reproducibility, data analysis, access) in translating spatial technologies to the clinic.
  

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